Neuroleptic Malignant Syndrome Associated with Quetiapine
Bibliographic record
Abstract
INTRODUCTION Neuroleptic malignant syndrome is a rare adverse effect of antipsychotic agents. The most common signs and symptoms are hyperthermia, muscle rigidity, changes in mental status, and autonomic instability.1 The prevalence of neuroleptic malignant syndrome in association with the use of typical antipsychotics is estimated at 0.5% to 1%.1 Atypical antipsychotics such as quetiapine have greater affinity for serotonin 5-HT2A receptors than for dopamine D2 receptors. Therefore, it is believed that atypical antipsychotics are less likely to cause this condition. This article describes a patient treated with quetiapine who presented with biochemical and clinical evidence of neuroleptic malignant syndrome.
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How this classification was reachedexpand
Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.000 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.001 |
| Insufficient payload (model declined to judge) | 0.001 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one teacher head, not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".