Bibliographic record
Abstract
Treatment resistant hypertension is defined as a blood pressure not achieving a goal blood pressure (<140/90 mm Hg) with a combination of three or more antihypertensive drugs. There are several causes for patients not responding to antihypertensive medication. One of the major reasons is noncompliance to the treatment, often because of real or perceived side effects or because of a great number of medications and frequent dosing. Exogenous substances, most frequently nonsteroidal anti-inflammatory drugs, and, often not recognized, over-the-counter medications containing ephedrine or pseudo-ephedrine, can reduce the effect of antihypertensive drugs. Obesity and obstructive sleep apnea oppose antihypertensive drug effects by several mechanisms but predominantly by an increase in the activity of the sympathetic and renin-angiotensin-aldosterone systems. White coat hypertension as a cause of treatment resistance is suspected if there is no target organ damage or if the patients complain of symptoms of hypotension during antihypertensive treatment. Secondary forms of hypertension, although comprising only approximately 5% of patients with treatment resistant hypertension, are important to identify because they may represent a curable form of hypertension.
Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.
How this classification was reachedexpand
Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.000 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.001 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.000 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one teacher head, not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".