Developmental changes in threshold, conduction velocity, and depressive action of lignocaine on dorsal root potentials from neonatal rats are associated with maturation of myelination
Bibliographic record
Abstract
Conduction velocity of primary afferent fibres and blocking actions of local anaesthetics seem to be developmentally regulated. The current work investigated physiological (threshold, conduction velocity, and myelination) and pharmacological (lignocaine (0.0625 to 2 mmol/L) and capsaicin (2 micromol/L)) ontogenic changes on in vitro sciatic nerve-dorsal root preparations from 0- to 12-day-old rats. As rats aged, stimulus intensities necessary to evoke A-fibre thresholds significantly decreased and A-fibre conduction velocities significantly increased. For C-fibres, thresholds significantly increased and conduction velocities significantly varied with age. The blocking potency of lignocaine varied with age: A-fibres from 4-day-old rats and younger were significantly more resistant than those from older rats, and C-fibres were blocked more uniformly amongst ages. Capsaicin significantly depressed C-fibres irrespective of age, and A-fibres were significantly reduced during the first postnatal week only. Myelination significantly increased as rats aged. A-fibre physiological parameters were significantly correlated with both other A-fibre physiological and pharmacological parameters, but C-fibre parameters were not. Peripheral A-fibre transduction mechanisms seem to require time to acquire their full stimulus-response sensitivity, which coincides with development of myelination. In contrast, peripheral C-fibres seem to have mature transduction mechanisms from the first days of postnatal life.
Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.
How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.000 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.001 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.001 |
| Insufficient payload (model declined to judge) | 0.002 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".