Suppression of cbfa1 expression in C3H10T1/2 mesenchymal stem cells by anti-cbfa1 siRNA blocks osteoblastic develoment, but does not affect chondrogenesis
Why this work is in the frame
A frame that forgets how it found something cannot be audited. These are the routes that admitted this work.
Bibliographic record
Abstract
Mesenchymal stem cells (MSC) may differentiate into adipocytes, osteoblasts or chondrocytes, the latter leading to hypertrophic chondrocytes responsible for endochondral ossification. The presence of the transcription factor cbfa1 is a prerequisite for osteoblast development, but is also of major importance in chondrocyte transition to the hypertrophic state. For cartilage tissue engineering, we need to prevent hypertrophic phenotype of MSC differentiated to chondrocytes. For this, we transfected mesenchymal stem cells transiently with anti-cbfa1 siRNA and investigated its effect on bone morphogenic protein (BMP)-2-induced osteogenesis in monolayer culture, or chondrogenesis in cultured micropellets.
Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.
Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.001 | 0.000 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.001 | 0.000 |
| Bibliometrics | 0.001 | 0.001 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.001 |
| Insufficient payload (model declined to judge) | 0.000 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it