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miRNAs in Vascular Angiogenesis

2010· book-chapter· en· W1849795946 on OpenAlexaff
Zhiguo Wang

Bibliographic record

VenueBENTHAM SCIENCE PUBLISHERS eBooks · 2010
Typebook-chapter
Languageen
FieldBiochemistry, Genetics and Molecular Biology
TopicCircular RNAs in diseases
Canadian institutionsUniversité de MontréalMontreal Heart Institute
Fundersnot available
KeywordsAngiogenesismicroRNABiologyCancer researchCell biologyGeneticsGene

Abstract

fetched live from OpenAlex

Several processes including endothelial angiogenesis, vascular neointimal lesion formation, vascular inflammation process, lipoprotein metabolism, and hypertension are critically involved in antherogenesis or atherosclerosis. This chapter aims to introduce the role of miRNAs in endothelial angiogenesis. Angiogenesis is the growth of new blood vessels from pre-existing vessels. Functional endothelial cells are required for angiogenesis, a process involving proliferation, migration, and maturation of endothelial cells. Several miRNAs have been shown to critically regulate vascular angiogenesis and they can be classified into pro-angiogenic miRNAs and anti-angiogenic miRNAs. Pro-angiogenic miRNAs indentified to date include miR-130a, miR- 17~92 cluster, miR-210, miR-378, miR-7f, miR-27b, and miR-126. The known anti-angiogenic miRNAs include miR-320, miR-221 and miR-222. In addition, the miRNAs that are reportedly involved in tumor vascular biology are also introduced in this chapter.

Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.

How this classification was reachedexpand

Full frame distilled prediction

Teacher imitation

Not calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.

metaresearch head score (Codex)0.001
metaresearch head score (Gemma)0.000
Version: codex-gemma-dda1882f352aValidation status: machine_predicted_unvalidated
Candidate categoriesMeta-epidemiology (narrow)
Consensus categoriesnone
DomainCandidate signal: none · Consensus signal: none
Study designCandidate signal: Not applicable · Consensus signal: none
GenreCandidate signal: Other · Consensus signal: Other
Teacher disagreement score0.932
Threshold uncertainty score1.000

Codex and Gemma teacher scores by category

CategoryCodexGemma
Metaresearch0.0010.000
Meta-epidemiology (narrow)0.0000.000
Meta-epidemiology (broad)0.0000.000
Bibliometrics0.0010.000
Science and technology studies0.0000.001
Scholarly communication0.0010.000
Open science0.0020.001
Research integrity0.0010.000
Insufficient payload (model declined to judge)0.0000.000

Machine scores (provisional)

The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.

Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.

Opus teacher head0.010
GPT teacher head0.231
Teacher spread0.220 · how far apart the two teachers sit on this one work
Validation statusscore_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it

Classification

machine, unvalidated

Machine predicted; a candidate call from one teacher head, not a consensus.

Study designNot applicable
Domainnot available
GenreOther

How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".

Quick stats

Citations0
Published2010
Admission routes1
Has abstractyes

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