A monolayer phase behaviour study of phosphatidylinositol, phosphatidylinositol 4-monophosphate and their binary mixtures with distearoylphosphatidylethanolamine
Bibliographic record
Abstract
The monolayer phase behaviour of phosphatidylinositol (PI), phosphatidylinositol 4-monophosphate (4-PIP) and their binary mixtures with distearoylphosphatidylethanolamine (DSPE) has been studied at the air/water interface. PI and 4-PIP exhibited a fluid phase at all surface pressures above 0 mN m−1. At a given surface pressure, 4-PIP monolayers yielded higher molecular areas than PI which was attributed to the increased repulsion due to the more highly charged headgroup. As expected, mixtures of PI with DSPE, which are known to have a condensed phase structure at all surface pressures above 0 mN m−1, exhibited an expansion of the film which increased with increasing proportions of PI. However, this was not observed for DSPE/4-PIP mixtures for which greater 4-PIP concentrations did not always induce a corresponding increase in molecular area. Both PI/DSPE and 4-PIP/DSPE mixed monolayers were found to deviate from either ideal mixing or complete immiscibility likely due to either an additional charge repulsion between headgroups or, less likely, to a partial miscibility of the inositols and DSPE in the fluid phase.
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How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.000 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.001 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".