Alkylation of guanosine and 2′-deoxyguanosine by o-quinone α-(p-anisyl)methide in aqueous solution
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Bibliographic record
Abstract
Rates of alkylation of guanosine and 2'-deoxyguanosine with o-quinone alpha-(p-anisyl)methide were measured by flash photolysis in a series of aqueous sodium hydroxide solutions and bicarbonate ion, t-butylhydrogenphosphonate ion, and biphosphate ion buffers. The data so obtained provide rate profiles for these nucleoside plus quinone methide reactions over the range pH = 7-14, which furnish guanosine and deoxyguanosine acidity constants consistent with literature information. These profiles also provide rate constants that show the reaction of o-quinone alpha-(p-anisyl)methide with guanosine and deoxyguanosine to be fairly fast processes, considerably faster than the biologically wasteful reaction of the quinone methide with water, which is the ubiquitous medium in biological systems; that makes the quinone methide a potent guonosine and deoxyguanosine alkylator.
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Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.000 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.001 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it