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Characterization of anemia and iron deficiency in 6–12 month old infants from rural India

2013· article· en· W186850660 on OpenAlexaff
K. Madhavan Nair, Sylvia Fernandez‐Rao, Nagalla Balakrishna, KV Radhakrishna, P Ravinder, Andrew Flower, Kristen Hurley, Nicholas Tilton, Kimberly Harding, Greg Reinhart, Maureen M. Black

Bibliographic record

VenueThe FASEB Journal · 2013
Typearticle
Languageen
FieldMedicine
TopicIron Metabolism and Disorders
Canadian institutionsNutrition International
Fundersnot available
KeywordsMedicineMicronutrientSoluble transferrin receptorVitamin B12Iron deficiencyAnemiaMicronutrient deficiencyFerritinPediatricsHemoglobinIron-deficiency anemiaGastroenterologyInternal medicinePhysiologyIron statusPathology

Abstract

fetched live from OpenAlex

Determining anemia and iron deficiency (ID) prevalence estimates in infants using stringent criteria are a critical step in designing effective prevention strategies. The objective was to characterize biomarkers of iron, folate and vitamin B12 status and inflammatory marker C ‐ reactive protein (CRP) in 6–12 month old infants. We enrolled 497 infants from rural Andhra Pradesh, India as part of an interventional study of simultaneous early learning stimulation and at‐home micronutrient fortification. At baseline, blood was collected from 483 infants. ID was diagnosed based on ferritin <12 μg/L or serum transferrin receptor (sTfR) >;2.5 mg/L and ID with hemoglobin (Hb) <11 g/dL as iron deficiency anemia (IDA) and cases which did not fit into the above categories as indeterminant. Prevalence of anemia was 67%: iron replete infants accounted for 27%; IDA 52%; ID 6% and indeterminant cases 15%. The prevalence of folate and vitamin B12 deficiency was <1% and 19%, respectively. Mean folate status was comparable among groups while vitamin B12 status was significantly lower in IDA compared to normal infants. Indeterminant infants exhibited significantly lower Hb and sTfR and higher ferritin and CRP compared to normal infants. These findings suggest that IDA is highly prevalent among infants. Research support: Mathile Institute & Micronutrient Initiative

Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.

How this classification was reachedexpand

Full frame machine prediction

Teacher imitation

Not calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.

metaresearch head score (Codex)0.000
metaresearch head score (Gemma)0.001
Version: metacan-v3-hybrid-931329e0061cValidation status: machine_predicted_unvalidated
Candidate categoriesnone
Consensus categoriesnone
DomainCandidate signal: none · Consensus signal: none
Study designCandidate signal: Observational · Consensus signal: Observational
GenreCandidate signal: Empirical · Consensus signal: Empirical
Teacher disagreement score0.011
Threshold uncertainty score0.023

Distilled classifier scores by category (both heads)

CategoryCodexGemma
Metaresearch0.0000.001
Meta-epidemiology (narrow)0.0000.000
Meta-epidemiology (broad)0.0000.000
Bibliometrics0.0010.001
Science and technology studies0.0000.000
Scholarly communication0.0000.000
Open science0.0000.000
Research integrity0.0000.000
Insufficient payload (model declined to judge)0.0010.000

Machine scores (provisional)

The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.

Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.

Opus teacher head0.007
GPT teacher head0.216
Teacher spread0.209 · how far apart the two teachers sit on this one work
Validation statusscore_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it

Classification

machine, unvalidated

Machine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.

The models applied no category: nothing in the taxonomy fit this work.
Study designObservational
Domainnot available
GenreEmpirical

How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".

Quick stats

Citations0
Published2013
Admission routes1
Has abstractyes

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