Metastatic adamantinoma responds to treatment with receptor tyrosine kinase and Aurora A kinase inhibitor
Bibliographic record
Abstract
Adamantinoma is to be known as the one of the least common low-grade malignant bone tumors, commonly arising in thecenter of long bones, mostly in the tibial mid shaft. Adamantinomas are usually managed with wide local excision andreconstruction, unless unresectable or locally recurrent. Even though adamantinomas are managed as locally aggressivetumors, they usually recur and metastasize to sites including the lymph nodes, lungs, skeleton, liver and brain.Radiotherapy and chemotherapy do not seem to be effective treatment modalities for adamantinoma; recently publishedcase reports suggest tyrosine kinase inhibitors as an alternative therapeutic strategy. We report a case of a patient withmetastatic adamantinoma who progressed after first line therapy with doxorubicin and cisplatin, and responded topazopanib (selective multi-targeted receptor tyrosine kinase inhibitor that inhibits angiogenesis) and alisertib (smallmolecule Aurora A kinase inhibitor) combination therapy. Tumor response to pazopanib and alisertib in combination as athird line therapy has led us to conclude that tyrosine kinase therapy could be considered in this setting.
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How this classification was reachedexpand
Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.000 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.001 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.000 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one teacher head, not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".