Why this work is in the frame
A frame that forgets how it found something cannot be audited. These are the routes that admitted this work.
Bibliographic record
Abstract
Research on leukocytoclastic vasculitis (LcV) provides insights into mechanisms of antibody-mediated immune responses as well as into the complex process of neutrophil transmigration. Clinical observations on immune complex vasculitis have revealed that adult patients with IgA containing immune complexes [Henoch-Schoenlein purpura (HSP)] have a higher rate of severe complications than children with HSP or adult patients with IgG or IgM containing immune complexes. This has direct impact on classification and management of vasculitis and warrants further studies on pathophysiology of IgA and on aberrant glycosylation of IgA1 associated with renal involvement. In order to dissect the pathomechanisms specific for LcV, we have been comparing different mouse models of LcV with a non-vasculitic, acute inflammation (i.e. irritant contact dermatitis). We found that one characteristic constellation in the vasculitis models encompasses interference with both normal transmigration and activation of neutrophils. Toxic products released by activated neutrophils have the potential to damage endothelial cells. However, one still needs to reveal how exactly they exert such damaging effects during diapedesis in vivo, considering the short contacts between neutrophils and endothelial cells. This review shows that research on LcV is embedded in an exciting context revealing special features of transmigration and antibody-mediated immune responses.
Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.
Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.000 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.001 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.000 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it