Cover Picture: Switchable Lipids: Conformational Change for Fast pH‐Triggered Cytoplasmic Delivery (Angew. Chem. Int. Ed. 43/2015)
Bibliographic record
Abstract
Liposomes must protect their cargo during delivery and then release it quickly and selectively at the target site. In their Communication on page 12743 ff., J. Leblond et al. present the development of switchable liposomes that exploit the acidification that occurs after endocytosis. These liposomes are stable for months under physiological conditions and release their content in less than 15 min at acidic pH values. This approach drastically improves drug delivery to the cytosol. Liposomes must protect their cargo during delivery and then release it quickly and selectively at the target site. In their Communication on page 12743 ff., J. Leblond et al. present the development of switchable liposomes that exploit the acidification that occurs after endocytosis. These liposomes are stable for months under physiological conditions and release their content in less than 15 min at acidic pH values. This approach drastically improves drug delivery to the cytosol. Pseudo-Dendrimers Structure-Directing Agents Biosynthesis
Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.
How this classification was reachedexpand
Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.000 |
| Meta-epidemiology (narrow) | 0.001 | 0.001 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.001 | 0.000 |
| Research integrity | 0.001 | 0.000 |
| Insufficient payload (model declined to judge) | 0.003 | 0.002 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; both teacher heads agree on what is shown here.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".