Vancomycin Overdose in a 6-Month-Old Girl
Bibliographic record
Abstract
INTRODUCTION Vancomycin is a commonly used antibiotic for the treatment of serious gram-positive infections. The use of this agent has increased over the past decade, as organisms have become increasingly resistant to penicillinase-resistant penicillins.1,2 Formal pharmacokinetics-based dosing strategies for infants were first reported in 1980.1 Since then, various dosing regimens for vancomycin have been studied in neonates and infants to take into account their differing kidney maturation status. Vancomycin dosing strategies typically target a “therapeutic range” (peaks of 20 to 40 mg/L, troughs of 5 to 10 mg/L) in an effort to enhance efficacy and minimize the potential toxic effects of the drug. The primary toxicities of concern to clinicians are ototoxicity and nephrotoxicity. However, definitive data that support concentration-efficacy or concentration-toxicity relationships for vancomycin are lacking.3 The following case illustrates the clinical course of an infant who was inadvertently given a 10-fold overdose of vancomycin.
Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.
How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.004 |
| Meta-epidemiology (narrow) | 0.002 | 0.001 |
| Meta-epidemiology (broad) | 0.002 | 0.001 |
| Bibliometrics | 0.002 | 0.001 |
| Science and technology studies | 0.003 | 0.002 |
| Scholarly communication | 0.001 | 0.002 |
| Open science | 0.001 | 0.002 |
| Research integrity | 0.006 | 0.007 |
| Insufficient payload (model declined to judge) | 0.004 | 0.001 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".