Disorders of cobalamin and folate metabolism
Bibliographic record
Abstract
The progressive myoclonus epilepsies (PMEs) are a rare group of disorders with varied causes manifested by myoclonus, often activated by movement or action, but also occurring at rest. The form of PME is particularly striking in many family members affected by autosomal dominant Alzheimer disease linked to chromosome 14. The presenting features are cognitive decline with prominent seizures and myoclonus. Myoclonus is frequently described as an early feature of patients with amyloid precursor (16) protein gene mutation pedigrees who have limb dyspraxia, brisk reflexes, visual disorientation, and slow gait. Toxic causes of myoclonus include the sialysis syndrome characterized by myoclonus, asterixis, speech disorder, seizures, personality changes, and progressive dementia. The use of serotonin reuptake inhibitors commonly used as antidepressants may lead to severe myoclonus described with the use of citalopram and risperidone. Cephalosporin toxicity, levetiracetam accumulation in renal failure, amlodipine and nifedipine can induce acute myoclonic jerking without convulsive seizures.
Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.
How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.000 |
| Meta-epidemiology (narrow) | 0.001 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.001 | 0.001 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.001 | 0.001 |
| Open science | 0.000 | 0.001 |
| Research integrity | 0.001 | 0.001 |
| Insufficient payload (model declined to judge) | 0.011 | 0.005 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".