Antitissue transglutaminase antibody determination versus upper endoscopic biopsy diagnosis of paediatric celiac disease
Bibliographic record
Abstract
European guidelines question the requirement for intestinal biopsies to diagnose celiac disease in children. To determine the specificity of serological diagnosis of celiac disease (CD) using antitissue transglutaminase antibody (aTTG) levels in a general pediatric referral population. Children referred from 2005 to 2008 with a positive aTTG test were included, regardless of symptoms. Diagnostic endoscopy was performed and a minimum of six biopsies were obtained. Histological samples were reviewed in a blinded manner, and specificities and sensitivities of aTTG threshold levels for a diagnostic Marsh score ≥3 were determined. A total of 115 eligible patients were identified, 73% of whom had a Marsh score ≥3. The specificity of an aTTG level of ≥100 U/mL was 97% (95% CI 93.5% to 100%); an aTTG level ≥200 U/mL was 100% (95% CI 89% to 100%) specific. Further research is required before considering a change in diagnostic standards in Canada. In this region, the threshold aTTG level to provide diagnostic specificity of 100% is significantly greater than the threshold aTTG level being proposed for diagnosis in Europe.
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How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.019 | 0.044 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.001 | 0.001 |
| Bibliometrics | 0.001 | 0.001 |
| Science and technology studies | 0.000 | 0.001 |
| Scholarly communication | 0.001 | 0.001 |
| Open science | 0.001 | 0.001 |
| Research integrity | 0.001 | 0.001 |
| Insufficient payload (model declined to judge) | 0.001 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".