Malignant Carcinoid Tumor of the Rectum in a Patient With Psoriatic Arthritis Treated With Etanercept
Bibliographic record
Abstract
The connection between malignancy risk and tumor necrosis factor alpha (TNFa) inhibitors is still a working field. Generally, less attention has been paid to their association with solid tumors compared to the mostly accepted risk for lymphoma. Etanercept is somewhat underrepresented compared to other drugs in the class and entities other than rheumatoid arthritis (RA) have not been widely included in large cohort studies exploring malignancy correlations. Nonetheless, lymphoma association to etanercept has been found in some series and many solid malignancies cases in the context of etanercept use for conditions other than RA have been described as single reports. We present the first described case of rectal carcinoid tumor developing after treatment with etanercept in a patient with psoriatic arthritis and explore the literature for evidence about the association between solid tumors and etanercept use in autoimmune diseases. J Med Cases. 2015;6(9):389-392 doi: http://dx.doi.org/10.14740/jmc2248w
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How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.002 |
| Meta-epidemiology (narrow) | 0.001 | 0.000 |
| Meta-epidemiology (broad) | 0.001 | 0.001 |
| Bibliometrics | 0.001 | 0.001 |
| Science and technology studies | 0.002 | 0.001 |
| Scholarly communication | 0.001 | 0.001 |
| Open science | 0.000 | 0.001 |
| Research integrity | 0.002 | 0.002 |
| Insufficient payload (model declined to judge) | 0.002 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".