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Record W1903523058 · doi:10.1038/nature14664

Comprehensive genomic profiles of small cell lung cancer

2015· article· en· W1903523058 on OpenAlexaff
Julie George, Jing Lim, Se Jin Jang, Yupeng Cun, Luka Ozretić, Gu Kong, Frauke Leenders, Xin Lü, Lynnette Fernandez‐Cuesta, Graziella Bosco, Christian Müller, Ilona Dahmen, Nadine S. Jahchan, Dian Yang, Anthony N. Karnezis, Dedeepya Vaka, Angela Torres, Maia Segura‐Wang, Jan O. Korbel, Roopika Menon, Sung‐Min Chun, Deokhoon Kim, Matt Wilkerson, Neil Hayes, David Engelmann, Brigitte M. Pützer, Marc Bos, Sebastian Michels, Ignacija Vlašić, Danila Seidel, Berit Pinther, Philipp Schaub, Christian Becker, Janine Altmüller, Jun Yokota, Takashi Kohno, Reika Iwakawa, Koji Tsuta, Masayuki Noguchi, Thomas Muley, Hans Hoffmann, Philipp A. Schnabel, Iver Petersen, Yuan Chen, Alex Soltermann, Verena Tischler, Chang‐Min Choi, Yong‐Hee Kim, Pierre P. Massion, Yong Zou, Dragana J. Jovanović, Milica Kontić, Gavin Wright, Prudence A. Russell, Benjamin Solomon, Ina Koch, Michael Lindner, Lucia Anna Muscarella, Annamaria la Torre, John K. Field, Marko Jakopović, Jelena Knežević, Esmeralda Castaños‐Vélez, Luca Roz, Ugo Pastorino, O.T. Brustugun, Marius Lund‐Iversen, Erik Thunnissen, Jens Köhler, Martin Schüler, Johan Botling, Martin Sandelin, Montse Sánchez‐Céspedes, Helga B. Salvesen, Viktor Achter, Ulrich Lang, Magdalena Bogus, Peter M. Schneider, Thomas Zander, Sascha Ansén, Michael Hallek, Jürgen Wolf, Martin Vingron, Yasushi Yatabe, William D. Travis, Peter Nürnberg, Christian Reinhardt, Sven Perner, Lukas C. Heukamp, Reinhard Büttner, Stefan A. Haas, Élisabeth Brambilla, Martin Peifer, Julien Sage, Roman K. Thomas

Bibliographic record

VenueNature · 2015
Typearticle
Languageen
FieldMedicine
TopicLung Cancer Research Studies
Canadian institutionsTerry Fox Research InstituteVancouver General Hospital
FundersNational Cancer InstituteNational Institutes of HealthStand Up To CancerDeutschen Konsortium für Translationale KrebsforschungAssociazione Italiana per la Ricerca sul CancroBundesministerium für Bildung und ForschungDeutsches Zentrum für LungenforschungEuropean Regional Development FundRoy Castle Lung Cancer FoundationEuropean CommissionUniversität zu KölnMinistero della SaluteDeutsche ForschungsgemeinschaftGenentechDeutsche Krebshilfe
KeywordsBiologyCancer researchSomatic cellGeneChromothripsisCancerCyclin D1MutationSuppressorMutantGeneticsTumor suppressor geneLung cancerSMARCA4CarcinogenesisGenome instabilityGene expressionCell cycleMedicinePathologyDNA damageDNA

Abstract

fetched live from OpenAlex
No abstract in any covered source. Its absence is recorded, not treated as a negative.

No abstract. This is not a gap in this database; OpenAlex has none either. 23.3% of the frame is in this state, and the screen finds HALF as much metaresearch here, so the absence is a measured bias rather than a missing field.

How this classification was reachedexpand

Full frame machine prediction

Teacher imitation

Not calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.

metaresearch head score (Codex)0.000
metaresearch head score (Gemma)0.001
Version: metacan-v3-hybrid-931329e0061cValidation status: machine_predicted_unvalidated
Candidate categoriesnone
Consensus categoriesnone
DomainCandidate signal: none · Consensus signal: none
Study designCandidate signal: Observational · Consensus signal: Observational
GenreCandidate signal: Empirical · Consensus signal: Empirical
Teacher disagreement score0.004
Threshold uncertainty score0.009

Distilled classifier scores by category (both heads)

CategoryCodexGemma
Metaresearch0.0000.001
Meta-epidemiology (narrow)0.0000.000
Meta-epidemiology (broad)0.0000.000
Bibliometrics0.0020.003
Science and technology studies0.0000.000
Scholarly communication0.0010.000
Open science0.0000.001
Research integrity0.0000.000
Insufficient payload (model declined to judge)0.0020.000

Machine scores (provisional)

The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.

Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.

Opus teacher head0.033
GPT teacher head0.362
Teacher spread0.330 · how far apart the two teachers sit on this one work
Validation statusscore_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it

Classification

machine, unvalidated

Machine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.

The models applied no category: nothing in the taxonomy fit this work.
Study designObservational
Domainnot available
GenreEmpirical

How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".

Quick stats

Citations2,386
Published2015
Admission routes1
Has abstractno

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