Compatibilité par évaluation visuelle du thiopental injectable lors de son administration en Y avec des médicaments usuels
Bibliographic record
Abstract
Resume Objectifs : En 2011, la compagnie Hospira cessa la commercialisation du thiopental. Toutefois, des tests de compatibilite etaient deja en cours a notre centre hospitalier, puisqu’il n’existe qu’un nombre limite de donnees disponibles concernant la compatibilite du thiopental injectable avec d’autres medicaments. L’objectif du projet etait de tester la compatibilite du thiopental administre en Y avec plusieurs medicaments frequemment utilises aux soins intensifs afin de guider les pharmaciens dans leurs recommandations lors d’administrations intraveineuses. Methode : La methodologie de l’etude est fort simple et comprend le melange un pour un du thiopental avec successivement plusieurs autres medicaments injectables et l’observation du melange sur une periode n’excedant pas quatre heures. Resultats : Une incompatibilite visuelle du thiopental avec une grande quantite d’autres medicaments est rapportee. Par ailleurs, parmi les medicaments testes, seuls l’insuline humaine, le lorazepam et le trimethoprim/sulfamethoxazole sont visuellement compatibles avec le thiopental lors d’une administration en Y. Conclusion : Les donnees publiees corroborent nos resultats dans plusieurs cas, demontrant le haut niveau d’incompatibilite du thiopental avec la majorite des autres medicaments testes. Ces donnees sont publiees dans l’eventualite d’une nouvelle possibilite de disposer de la molecule, en supposant une formulation similaire a celle du produit teste. Abstract Objective: In 2011, Hospira stopped marketing thiopental. However, compatibility testing was already underway at our hospital, since there was a limited number data on the compatibility of injectable thiopental with other drugs. The objective of this project was to test the compatibility of thiopental administered via Y-site with a number of drugs frequently used in intensive care, and to guide pharmacists in their recommendations. Method: The study methodology consisted in mixing, one by one, thiopental with a number of injectable drugs and observing the mixture for a period not exceeding 4 hours. Results: Visual incompatibility between thiopental and a number of other drugs is reported. Of the drugs tested, only human insulin, lorazepam and trimethoprim/sulfamethoxazole were visually compatible with thiopental during Y-site administration. Conclusion: In many cases, published data corroborate our results, which show a high level of incompatibility of thiopental with most of the other drugs tested. These data are being published in the event that thiopental becomes available again, assuming a formulation similar to that of the product that was tested.
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How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.003 | 0.004 |
| Meta-epidemiology (narrow) | 0.001 | 0.001 |
| Meta-epidemiology (broad) | 0.001 | 0.001 |
| Bibliometrics | 0.001 | 0.001 |
| Science and technology studies | 0.000 | 0.001 |
| Scholarly communication | 0.001 | 0.001 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.001 | 0.001 |
| Insufficient payload (model declined to judge) | 0.004 | 0.001 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".