Papel del óxido nítrico en la fisiologïa normal de la vía aérea y sus implicaciones en la fisiopatología de la hipertensión pulmonar
Bibliographic record
Abstract
La hipertension pulmonar es una patologia de la microvasculatura pulmonar, caracterizada por un estado de vasoconstriccion, proliferacion endotelial, proliferacion de musculo liso y trombosis. Se han implicado diversas moleculas en su etiologia, demostrandose una produccion elevada de agentes vasoconstrictores, mitogenicos, protromboticos y mediadores proinflamatorios como tromboxano A2, endotelina (ET), el inhibidor del activador del plasminogeno y una menor produccion de sustancias vasodilatadoras como la prostaciclina (PGI2) y el oxido nitrico (ON), que en condiciones fisiologicas actua modulando el tono basal de los vasos pulmonares y tambien como mediador inflamatorio e inmunomodulador. La histopatologia de las lesiones en la hipertension pulmonar sugiere que el dano en el endotelio y los estimulos proliferativos son procesos fundamentales de su desarrollo, desencadenados por alteraciones en la produccion o en la actividad del ON, ocasionados por acumulacion de radicales libres que lleva a menor biodisponibilidad del ON. En el presente articulo se revisa el papel que juega el ON en la fisiologia normal de la via aerea y sus implicaciones en la fisiopatologia de la hipertension pulmonar.
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How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.001 | 0.001 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.001 | 0.000 |
| Science and technology studies | 0.000 | 0.001 |
| Scholarly communication | 0.001 | 0.001 |
| Open science | 0.000 | 0.001 |
| Research integrity | 0.001 | 0.001 |
| Insufficient payload (model declined to judge) | 0.002 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".