Hyperhemolysis Syndrome in a Patient With B-Thalassemia Due to an Anti-Jka Alloantibody
Bibliographic record
Abstract
Hyperhemolysis syndrome (HS) is a delayed type of transfusion reactions (DTHRs). These may occur in patients with hemoglobinopathies due to destruction of red blood cells (RBCs). A 17-year-old boy with B-thalassemia and a history of multiple transfusions, after several RBCs transfusions developed hemolysis and hemoglobinuria with a decreased hemoglobin (Hb) level in the absence of bleeding that continued with splenomegaly. The antibody screen test (LISS AHG) and direct anti-globulin test (DAT) were performed. An 11-cell antibody identification panel (IBTO home-made) was used. Acid elution procedure was done using a commercial kit. The patient RBC phenotyping was attempted by treating the cells, following a chloroquine treatment procedure. Laboratory findings showed that his blood group was “A” Rh positive. His RBC phenotyping was negative for Jka antigen. The LISS antibody screening test result was negative with a weakly positive auto control result but DAT was positive for both C3d and IgG. The antibody identification test showed the presence of anti-Jka alloantibody and also anti-Jka was identified with eluate reacting stronger with homozygous cells (Jka+Jka+). The patient received steroid and IVIG as the main treatment and followed by receiving compatible blood units but hemolysis was not resolved and his Hb level was not increased, finally he was splenectomized. The patient’s Hb level and clinical symptoms improved after the splenectomy, showing that the spleen may have a role in the destruction of the recipient and the donor blood cells. J Hematol. 2015;4(3):210-213 doi: http://dx.doi.org/10.14740/jh209w
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How this classification was reachedexpand
Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.000 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.001 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.000 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one teacher head, not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".