Modulation by Central and Basolateral Amygdalar Nuclei of Dopaminergic Correlates of Feeding to Satiety in the Rat Nucleus Accumbens and Medial Prefrontal Cortex
Why this work is in the frame
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Bibliographic record
Abstract
Current studies raise the possibility that subregions within the amygdala may interact with the mesocorticolimbic dopamine (DA) system to subserve specific psychological processes underlying food reward. The present study compared the effect of reversible inactivation of the central nucleus (CeN) versus the basolateral amygdala (BLA) on DA efflux in the nucleus accumbens (NAc) and medial prefrontal cortex (mPFC) in hungry rats that were tested in a food-devaluation procedure. During DA microdialysis experiments, lidocaine, a sodium channel blocker, was delivered via reverse dialysis into the CeN or BLA while rats were given two consecutive meals of Froot Loops. Loss of CeN function impaired the development of satiety during an initial meal and, consequently, diminished the effect of devaluation by satiety on intake of the same food during a second meal. Inactivation of the CeN was also associated with decreased basal levels of DA efflux in the NAc before food intake and attenuated increases in DA efflux related to anticipatory and consummatory aspects of feeding in both the NAc and mPFC. In contrast, inactivation of the BLA did not affect feeding behavior or DA efflux. Overall, these findings indicate that the CeN and BLA independently modulate DA transmission in both terminal regions. It is proposed that interaction between the CeN and mesocorticolimbic DA activity may be a mechanism by which hunger and satiety signals influence the value of food reward, or alternatively, a mechanism by which memory for a recently consumed food regulates food intake.
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Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.000 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.001 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.000 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it