Pituitary Metastasis From Breast Cancer Presenting as SIADH
Bibliographic record
Abstract
Pituitary metastasis is rare and unusual but can be seen in advanced breast and lung cancers with patients presenting with symptoms that range from mild headaches to seizures and altered mental status due to hyponatremia. A 53-year-old female with invasive ductal carcinoma of the left breast which was hormone positive, presented 5 years after completion of therapy with a dry cough, hyponatremia, weakness and visual disturbance. An MRI of the brain revealed a pituitary mass, compressing the optic chiasm. Hyponatremia was found to be due to SIADH. Biopsy confirmed metastatic breast carcinoma. Metastatic spread to the pituitary gland is rare (comprising less than 1% of pituitary tumors) but can occur in patients with advanced breast and lung cancers. Presentation with SIADH has previously not been reported with metastases due to breast cancer. Diagnosis may require biopsy or resection of the pituitary. Despite aggressive intervention, the prognosis is poor. J Endocrinol Metab. 2015;5(4):256-260 doi: http://dx.doi.org/10.14740/jem295w
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How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.002 |
| Meta-epidemiology (narrow) | 0.001 | 0.000 |
| Meta-epidemiology (broad) | 0.001 | 0.000 |
| Bibliometrics | 0.001 | 0.001 |
| Science and technology studies | 0.001 | 0.001 |
| Scholarly communication | 0.001 | 0.001 |
| Open science | 0.000 | 0.001 |
| Research integrity | 0.001 | 0.001 |
| Insufficient payload (model declined to judge) | 0.003 | 0.001 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".