Epigenetic silencing of miR-145-5p contributes to brain metastasis
Why this work is in the frame
A frame that forgets how it found something cannot be audited. These are the routes that admitted this work.
Bibliographic record
Abstract
// Sara Donzelli 1 , Federica Mori 2 , Teresa Bellissimo 1 , Andrea Sacconi 1 , Beatrice Casini 3 , Tania Frixa 1 , Giuseppe Roscilli 4 , Luigi Aurisicchio 4 , Francesco Facciolo 5 , Alfredo Pompili 6 , Maria Antonia Carosi 3 , Edoardo Pescarmona 3 , Oreste Segatto 7 , Greg Pond 8 , Paola Muti 8 , Stefano Telera 6 , Sabrina Strano 2,8 , Yosef Yarden 9 and Giovanni Blandino 1,8 1 Translational Oncogenomics Unit, Italian National Cancer Institute ‘Regina Elena’, Rome, Italy 2 Molecular Chemoprevention Unit, Italian National Cancer Institute ‘Regina Elena’, Rome, Italy 3 Department of Pathology, Italian National Cancer Institute ‘Regina Elena’, Rome, Italy 4 Takis s.r.l., Roma, Italy 5 Unit of Thoracic Surgery, Italian National Cancer Institute ‘Regina Elena’, Rome, Italy 6 Department of Neurosurgery, Italian National Cancer Institute ‘Regina Elena’, Rome, Italy 7 Laboratory of Cell Signaling, Italian National Cancer Institute ‘Regina Elena’, Rome, Italy 8 Department of Oncology, Faculty of Health Science, McMaster University, Hamilton, Canada 9 Weizmann Institute of Science, Department of Biological Regulation, Rehovot, Israel Correspondence to: Giovanni Blandino, email: // Keywords : brain metastases; lung cancer; mir-145-5p; epigenetic modifications; migration Received : June 27, 2015 Accepted : September 14, 2015 Published : September 30, 2015 Abstract Brain metastasis is a major cause of morbidity and mortality of lung cancer patients. We assessed whether aberrant expression of specific microRNAs could contribute to brain metastasis. Comparison of primary lung tumors and their matched metastatic brain disseminations identified shared patterns of several microRNAs, including common down-regulation of miR-145-5p. Down-regulation was attributed to methylation of miR-145’s promoter and affiliated elevation of several protein targets, such as EGFR, OCT-4, MUC-1, c-MYC and, interestingly, tumor protein D52 (TPD52). In line with these observations, restored expression of miR-145-5p and selective depletion of individual targets markedly reduced in vitro and in vivo cancer cell migration. In aggregate, our results attribute to miR-145-5p and its direct targets pivotal roles in malignancy progression and in metastasis.
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Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.001 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.000 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it