Bibliographic record
Abstract
This is the first real documentation of up-regulated activated NMDA receptors in human epilepsy. Refractory seizures lead to a variety of changes in neuronal receptors and transport mechanisms across the blood–brain barrier (BBB).1 As seizures remain uncontrolled, these particular changes can lead to pharmacoresistance patterns commonly seen in resistant epilepsy, status epilepticus (SE), refractory SE (RSE) and super-refractory SE (SRSE). First, γ aminobutyric acid type-A (GABAA) receptor downregulation, followed by subunit changes can lead to resistance to GABA mediated antiepileptic drugs (AEDs). Second, upregulation of the p-glycoprotein BBB transporter can lead to exportation of phenytoin and phenobarbital molecules, resulting in decreased efficacy of these medications. Finally, N -methyl-d-aspartate (NMDA) receptor upregulation has …
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How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.001 | 0.006 |
| Meta-epidemiology (narrow) | 0.001 | 0.000 |
| Meta-epidemiology (broad) | 0.001 | 0.001 |
| Bibliometrics | 0.001 | 0.000 |
| Science and technology studies | 0.001 | 0.002 |
| Scholarly communication | 0.002 | 0.004 |
| Open science | 0.001 | 0.001 |
| Research integrity | 0.009 | 0.012 |
| Insufficient payload (model declined to judge) | 0.002 | 0.002 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".