Vascular responsiveness determined by near‐infrared spectroscopy measures of oxygen saturation
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Bibliographic record
Abstract
New Findings What is the central question of this study? Can the near‐infrared spectroscopy (NIRS)‐derived reperfusion rate (slope 2) of tissue oxygen saturation ( S tO 2 ) be correlated with flow‐mediated dilation (FMD), the commonly used method to assess vascular endothelial function? What is the main finding and its importance? The present data were able to establish a correlation between the reperfusion rate of S tO 2 and percentage FMD in healthy young men. These data suggest that NIRS‐derived slope 2 S tO 2 can be used as a measure of vascular endothelial function. Vascular impairments at the macro‐ and microcirculatory levels are associated with increased risk for cardiovascular disease. Flow‐mediated dilation (FMD) is currently the most widely used method for non‐invasive assessment of vascular endothelial function. Recently, near‐infrared spectroscopy (NIRS)‐derived measures of tissue oxygen saturation ( S tO 2 ) have been used to characterize the dynamic response of local tissue perfusion to a brief period of ischaemia. The purpose of the present study was to establish correlations between the reperfusion rate of S tO 2 and FMD. Ultrasound‐derived FMD was quantified after 5 min of distal cuff occlusion of the popliteal artery in 20 healthy young men (26 ± 3 years old). Triplicate measurements of end‐diastolic arterial diameter were made every 15 s after cuff release, and FMD response was calculated as the greatest percentage change in diameter from baseline (%FMD). The S tO 2 was measured using NIRS throughout the duration of each test. Two consecutive FMD tests were performed, separated by 30 min of rest, and were averaged for %FMD and S tO 2 . The %FMD was significantly correlated with the reperfusion slope of S tO 2 after cuff release (slope 2 S tO 2 ; r = 0.63, P = 0.003). In conclusion, the present study established a correlation between slope 2 S tO 2 and %FMD in healthy young men. These data suggest that NIRS‐derived slope 2 S tO 2 can be used as a measure of vascular endothelial function.
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Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.000 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.000 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it