Outcomes of Patients with Takayasu Arteritis Treated with Infliximab
Bibliographic record
Abstract
To the Editor: Takayasu arteritis (TA) is a chronic vasculitis of unknown etiology involving the aorta and its main branches. Progression may lead to stenosis or formation of aneurysms1. Current therapy is based on corticosteroids and immunosuppressive agents. Treatment with anti-tumor necrosis factor-α (anti-TNF-α) has shown efficacy, as well as unfavorable outcomes2,3,4,5,6,7. From a cohort of 14 patients with TA refractory to conventional treatments, we treated 3 with infliximab (IFX), and describe the outcome. A 21-year-old woman was admitted because of 6 months of progressive chest pain, palpitations, and claudication in the left upper limb. Examination showed differential blood pressure between arms, decreased pulses in the left arm, bilateral carotid, and mitral murmur; erythrocyte sedimentation (ESR) rate was 54 mm/h and C-reactive protein (CRP) was 3 mg/dl. Angiography study showed stenosis in the thoracic aorta and supraaortic and renal vessels compatible with a diagnosis … Address correspondence to Dr. Cañas; E-mail: cacd12{at}hotmail.com
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How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.005 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.001 | 0.000 |
| Bibliometrics | 0.001 | 0.001 |
| Science and technology studies | 0.001 | 0.000 |
| Scholarly communication | 0.001 | 0.001 |
| Open science | 0.001 | 0.000 |
| Research integrity | 0.003 | 0.001 |
| Insufficient payload (model declined to judge) | 0.002 | 0.001 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".