MRI patterns of atrophy associated with progression to AD in amnestic mild cognitive impairment

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A frame that forgets how it found something cannot be audited. These are the routes that admitted this work.

No Canadian affiliation. An affiliation-only frame — the usual design — would never have seen this work. It is one of the works that make the case for inverting the frame.

Machine scores (provisional)

The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.

Teacher spread

0.313 · how far apart the two teachers sit on this one work

Validation status

score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it

Abstract

<b>Objective: </b> To compare the patterns of gray matter loss in subjects with amnestic mild cognitive impairment (aMCI) who progress to Alzheimer disease (AD) within a fixed clinical follow-up time vs those who remain stable. <b>Methods: </b> Twenty-one subjects with aMCI were identified from the Mayo Clinic Alzheimer9s research program who remained clinically stable for their entire observed clinical course (aMCI-S), where the minimum required follow-up time from MRI to last follow-up assessment was 3 years. These subjects were age- and gender-matched to 42 aMCI subjects who progressed to AD within 18 months of the MRI (aMCI-P). Each subject was then age- and gender-matched to a control subject. Voxel-based morphometry (VBM) was used to assess patterns of gray matter atrophy in the aMCI-P and aMCI-S groups compared to the control group, and compared to each other. <b>Results: </b> The aMCI-P group showed bilateral loss affecting the medial and inferior temporal lobe, temporoparietal association neocortex, and frontal lobes, compared to controls. The aMCI-S group showed no regions of gray matter loss when compared to controls. When the aMCI-P and aMCI-S groups were compared directly, the aMCI-P group showed greater loss in the medial and inferior temporal lobes, the temporoparietal neocortex, posterior cingulate, precuneus, anterior cingulate, and frontal lobes than the aMCI-S group. <b>Conclusions: </b> The regions of loss observed in subjects with amnestic mild cognitive impairment (aMCI) who progressed to Alzheimer disease (AD) within 18 months of the MRI are typical of subjects with AD. The lack of gray matter loss in subjects with aMCI who remained clinically stable for their entire observed clinical course is consistent with the notion that patterns of atrophy on MRI at baseline map well onto the subsequent clinical course. <b>GLOSSARY: </b><b>AD</b> = Alzheimer disease; <b>ADNI</b> = Alzheimer9s Disease Neuroimaging Initiative; <b>ADPR</b> = Alzheimer9s Disease Patient Registry; <b>ADRC</b> = Mayo Clinic Alzheimer9s Disease Research Center; <b>aMCI</b> = amnestic mild cognitive impairment; <b>APOE e4</b> = apolipoprotein epsilon 4; <b>AVLT</b> = Auditory Verbal Learning Test; <b>CDR-SB</b> = CDR sum of boxes; <b>DCT</b> = discrete cosine transformation; <b>FDR</b> = false discovery rate; <b>FWHM</b> = full-width at half-maximum; <b>GM</b> = gray matter; <b>MMSE</b> = Mini-Mental State Examination; <b>MNI</b> = Montreal Neurological Institute; <b>NIA</b> = National Institute on Aging; <b>TIV</b> = total intracranial volume; <b>VBM</b> = voxel-based morphometry; <b>WM</b> = white matter; <b>WMH</b> = white matter hyperintensity.

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The record

Venue

Neurology

Topic

Dementia and Cognitive Impairment Research

Field

Medicine

Canadian institutions

—

Funders

National Institute on Aging

Keywords

AtrophyCognitive impairmentMedicineCognitionNeuroscienceMagnetic resonance imagingPsychologyPathologyRadiology

Has abstract in OpenAlex

yes

API

/api/v1/works/W1964049567