The corticotropin-releasing factor system as a potential target for antiobesity drugs
Bibliographic record
Abstract
Corticotropin-releasing factor (CRF)-related peptides are involved in numerous physiological and behavioral actions, including activation of the pituitary-adrenal axis, stimulation of anxiety-related behaviors and modulation of cardiovascular and gastrointestinal functions. They are also capable of strong anorectic and thermogenic effects. In fact, the CRF system, which promotes a negative energy profile upon activation, could represent a potential target for the pharmacological treatment of obesity. The recent identification of two endogenous ligands for the CRF(2) receptor, urocortins 2 and 3, and the development of selective CRF receptor antagonists, has paved the way for improving our understanding of the specific physiological roles played by each CRF receptor. Based on recent progress, we conclude that the CRF(2) receptor could be a potential target for the development of an antiobesity drug.
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How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.001 | 0.000 |
| Meta-epidemiology (narrow) | 0.001 | 0.000 |
| Meta-epidemiology (broad) | 0.001 | 0.000 |
| Bibliometrics | 0.002 | 0.001 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.001 | 0.002 |
| Open science | 0.001 | 0.000 |
| Research integrity | 0.001 | 0.001 |
| Insufficient payload (model declined to judge) | 0.006 | 0.004 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".