Ventilation and metabolism during propofol anesthesia in rats
Bibliographic record
Abstract
Many anesthetics are known to decrease ventilation (V(E)) and metabolic rate (MR). Because MR is known to contribute to the V(E) level, one would expect some parallelism between the changes in V(E) and MR during anesthesia. We tested this hypothesis in normoxia and hypoxia (12% O2) on male Wistar rats (n = 10; 221-288 g) by using a short-acting intravenous anesthetic, propofol. Propofol anesthesia was induced with a 7-7.5 mg kg(-1) (60-70 s) dose and maintained with a 20-22 mg kg(-1) h(-1) (<40 min) dose. In normoxia, propofol significantly decreased V(E) and MR and maintained the V(E)/MR ratio. In hypoxia, propofol decreased MR without a significant decrease in V(E), and the V(E)/MR ratio tended to increase. As a result, both in normoxia and hypoxia, propofol did not significantly increase the partial pressure of CO2 in arterial blood (PaCO2). Propofol was also associated with decreased body temperature and mean arterial pressure. The results suggest that during anesthesia, a large part of the drop in V(E) can be accounted for by the drop in MR, and that in both normoxia and hypoxia the V(E)/MR ratios and PaCO2values are maintained close to the levels of the conscious state.
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How this classification was reachedexpand
Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.000 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.000 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one teacher head, not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".