Introduction to the 57th Annual Thomas L. Petty Aspen Lung Conference: Rebuilding the Injured Lung
Bibliographic record
Abstract
For 4 days each June in Aspen, Colorado, the Thomas L. Petty Aspen Lung Conference provides an international forum for the presentation, discussion, and integration of contemporary and emerging clinical, translational, and basic science investigations of a specific lung disease or topic. Building on the conceptual framework of the 2007 Conference titled “Lung Injury and Repair,” the 2014 Conference addressed the central question: “How can knowledge of the mechanisms of acute and chronic alveolar injury be translated into specific approaches to reconstitute and rebuild the injured lung?” Figure 1. The 57th meeting of the Thomas L. Petty Aspen Lung Conference. Left to right: Eric Schmidt, M.D., Gregory Downey, M.D., David Riches, Ph.D., Peter Bitterman, M.D., Ellen Burnham, M.D., and Marc Moss, M.D. The program was organized into six thematic half-day sessions, with each successive session building on the concepts and data presented in the previous session. The first day was anchored by State of the Art presentations by Marco Ranieri, M.D. (Milan, Italy), Peter Henson, M.D., Ph.D., D.V.M. (Denver, CO), Rachel Chambers, Ph.D. (London, UK), and Dean Sheppard, M.D. (San Francisco, CA) and focused attention on the clinical challenges and basic mechanisms that distinguish acute lung injury from more chronic and progressive pulmonary injury and fibrosis. With key presentations by Daniel Tschumperlin, Ph.D. (Rochester, MN) and Eric White, M.D. (Ann Arbor, MI), the focus of the second day moved to consideration of the complex interactions between epithelial cells and mesenchymal cells and the extracellular connective tissue matrix. Then, with presentations by Oliver Eickelberg, M.D. (Munich, Germany), Don Dong-Huh, M.D. (Philadelphia, PA), Harald Ott, M.D. (Boston, MA), and Darrell Kotton, M.D., (Boston), the theme of the third day shifted to consider how understanding of matrix, epithelial, endothelial, and induced pleuripotential stem cell biology can be harnessed to repair injured lungs in animal models and ultimately in human subjects. Featuring presentations by Michael Matthay, M.D. (San Francisco) and Gordon Rubenfeld, M.D. (Toronto, ON, Canada), the final day focused on the state of the art of human mesenchymal stem cell delivery and novel clinical trial design approaches that are hoped to provide new avenues to improve therapies directed at repairing the injured lung. Finally, as has been a tradition since the first Aspen Lung Conference in 1958, the 2014 Conference concluded with a thoughtful and thoroughly comprehensive summary, presented this year by Peter Bitterman, M.D. (Minneapolis, MN). We are deeply indebted to Peter for taking on this task and for so skillfully integrating the clinical, translational, and basic science presented at the meeting. The meeting was attended by 160 participants from 10 countries and, in addition to the 12 State of the Art presentations, featured 24 short oral presentations and 40 posters, the latter being presented in two thematic poster sessions that were held outdoors under sunny skies in a stunningly beautiful setting. Also, for the first time, the 2014 Conference featured “Meet the Speakers” coffee breaks in which the State of the Art presenters discussed science, pulmonary medicine, or pretty much anything with junior investigators and postdoctoral students. Finally, we express our sincere thanks to the many individuals and entities who helped make this year’s conference possible. The Thomas L. Petty Aspen Lung Conference continues to support participation by not charging a registration fee and by providing traveling fellowship grants. To disseminate the information presented at the Conference, the conference proceedings are published. We are therefore deeply grateful to the National Heart, Lung, and Blood Institute, Novartis, Amgen, InterMune, Boehringer-Ingleheim Pharmaceuticals Inc., the Francis Family Foundation, University of Colorado Health, and the many other benefactors listed in this issue of the Annals of the American Thoracic Society who have generously provided educational grants to help support the Conference. And last, but not least, we thank our Conference Administrators, Jeanne and Melissa Cleary, who, once again, did an outstanding job in coordinating and administering this year’s conference. The manuscripts and Conference Summary presented in this issue of the Annals of the American Thoracic Society reflect four outstanding and memorable days of discourse, discovery, discussion, and contemporary thinking about how acute and progressive lung injury can be resolved and repaired. Whether you attended the 57th Thomas L. Petty Aspen Lung Conference or not, we hope you enjoy reading these contributions and are stimulated in your thinking about strategies for “Rebuilding the Injured Lung.”
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How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.002 | 0.003 |
| Meta-epidemiology (narrow) | 0.001 | 0.000 |
| Meta-epidemiology (broad) | 0.001 | 0.001 |
| Bibliometrics | 0.001 | 0.001 |
| Science and technology studies | 0.002 | 0.001 |
| Scholarly communication | 0.006 | 0.002 |
| Open science | 0.001 | 0.003 |
| Research integrity | 0.003 | 0.005 |
| Insufficient payload (model declined to judge) | 0.148 | 0.061 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".