Oseltamivir was safe and effective for prophylaxis of influenza in the frail elderly
Bibliographic record
Abstract
(2001) J Am Geriatr Soc 49, 1025. Peters PH Jr, Gravenstein S, Norword P . , et al. . Long-term use of oseltamivir for the prophylaxis of influenza in a vaccinated frail older population. . Aug; . : . –31 . [OpenUrl][1][CrossRef][2][PubMed][3][Web of Science][4] QUESTION: In frail older people in a residential setting, is oseltamivir (a neuraminidase inhibitor) safe and effective in preventing influenza A and B? Randomised (allocation concealed** placebo controlled trial with 8 weeks of follow up. 31 residential homes or sheltered accommodations for seniors in 5 countries during the 1998–99 influenza season. 572 people who were ≥ 65 years of age, resided in care homes for seniors, and scored ≥ 7 on a Mental Status Questionnaire. Exclusion criteria included antibiotic treatment for acute upper respiratory tract infection, otitis media, bronchitis, or sinusitis, and antiviral treatment for influenza in the previous 2 weeks. 548 people (mean age 81 y, 69% women), of whom 80% were vaccinated against influenza, received ≥ 1 dose of study drug and … [1]: {openurl}?query=rft.jtitle%253DJournal%2Bof%2Bthe%2BAmerican%2BGeriatrics%2BSociety%26rft.stitle%253DJ%2BAm%2BGeriatr%2BSoc%26rft.aulast%253DPeters%26rft.auinit1%253DP.%2BH.%26rft.volume%253D49%26rft.issue%253D8%26rft.spage%253D1025%26rft.epage%253D1031%26rft.atitle%253DLong-term%2Buse%2Bof%2Boseltamivir%2Bfor%2Bthe%2Bprophylaxis%2Bof%2Binfluenza%2Bin%2Ba%2Bvaccinated%2Bfrail%2Bolder%2Bpopulation.%26rft_id%253Dinfo%253Adoi%252F10.1046%252Fj.1532-5415.2001.49204.x%26rft_id%253Dinfo%253Apmid%252F11555062%26rft.genre%253Darticle%26rft_val_fmt%253Dinfo%253Aofi%252Ffmt%253Akev%253Amtx%253Ajournal%26ctx_ver%253DZ39.88-2004%26url_ver%253DZ39.88-2004%26url_ctx_fmt%253Dinfo%253Aofi%252Ffmt%253Akev%253Amtx%253Actx [2]: /lookup/external-ref?access_num=10.1046/j.1532-5415.2001.49204.x&link_type=DOI [3]: /lookup/external-ref?access_num=11555062&link_type=MED&atom=%2Febmed%2F7%2F1%2F10.atom [4]: /lookup/external-ref?access_num=000170656700002&link_type=ISI
Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.
How this classification was reachedexpand
Direct model labels (unvalidated)
Per-model category and study-design labels from the labeling rounds. They are machine output, unvalidated, and the disagreement between models ships as data. No study design here is MEDLINE-validated yet.
| Model arm | Categories | Study design | Confidence |
|---|---|---|---|
| gemma | no category Domain: not available · Genre: Empirical About the Canadian research system: no · About a Canadian topic: no | Non-randomized trial | low |
| gpt | no category Domain: not available · Genre: Empirical About the Canadian research system: no · About a Canadian topic: no | Randomized trial | low |
Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.002 | 0.014 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.001 | 0.000 |
| Bibliometrics | 0.000 | 0.001 |
| Science and technology studies | 0.000 | 0.001 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.000 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedLabeled directly by 2 models reading the full record.
The models disagree on parts of this classification; every voice is preserved in the section at the end of the page.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".