In vivo Phosphorylation of Myelin Basic Proteins in Developing Mouse Brain: Evidence that Phosphorylation Is an Early Event in Myelin Formation
Why this work is in the frame
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Bibliographic record
Abstract
Myelin basic proteins (MBPs) can be detected in 5-day mouse brain, even though there is very little myelin present. In addition to the 4 MBP components (with molecular weights of 14, 17, 18.5 and 21.5 kilodaltons), that are commonly observed, other larger MBP-related polypeptides are also present. We have investigated the possibility of MBP phosphorylation at early stages of development in order to establish the point at which this modification occurs in the assembly of myelin. In vivo isotope studies show that in the 5-day mouse brain 14-, 17-, 18.5- and 21.5- kilodalton MBPs are phosphorylated and that they may be present in an immature form of myelin. Larger MBP-related proteins with a molecular weight of 35 and 42 kilodaltons are also phosphorylated but appear to be present mostly in nonmyelin structures or compartments.
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Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.001 | 0.000 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.000 | 0.001 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.000 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it