Elevated plasma coagulation FXIIA levels and high ?new pressor protein? (npp) activity in pediatric hemodialysis patients with unexplained renoprival hypertension*1
Bibliographic record
Abstract
Unexplained hypertension was observed in three anephric children on hemodialysis. We therefore investigated possible involvement by the novel extra-renal enzyme ‘New Pressor Protein’ (NPP) which is structurally related to coagulation β-FXIIa (J Hypertens 16:311-320, 1998; Can J Cardiol 18(10):1077-1086; 1093-1103, 2002) and produces potent hypertensive cardiovascular and sympatho-adrenal effects. NPP activity (ΔSBP mmHg) from normal human plasma (NHP, 250μL i.v.) and from our patients’ plasmas (250μL i.v.) were measured in male Wistar bioassay rats (∼300g), anesthetized with Inactin (100 mg/kg i.p.) and given Pentolinium (19.2 mg/kg s.c.) and Captopril (2.5 mg/kg i.v.). The SBP increments (Δ mmHg) were recorded using a MacLab/8 PowerMac 7200 computerized system. Plasma FXIIa levels in NHP and patients’ plasmas were determined by immunoassay (Axis-Shield Diagnostics Ltd., Dundee, UK). Pre-dialysis, patients AS and HI were hypertensive and their plasmas exhibited abnormally high NPP activity and plasma FXIIa levels. Post-dialysis, patients AS and HI reached their estimated dry body weight and their systemic pressures dropped in parallel with both NPP activity and plasma FXIIa levels. Patient JS remained hypertensive and hypervolemic, both pre- and post-dialysis, and NPP activity and plasma FXIIa levels dropped but still remained abnormally high. Our data suggest that high endogenous plasma NPP activity and FXIIa levels exist in these hemodialysis patients and change in relation to systemic BP and fluid volume status enough to suggest involvement in their hypertension (see Table). NPP activity (ΔSBP, mmHg). Means ± SEM. p < 0.01 vs. NHP. NPP activity (ΔSBP, mmHg). Means ± SEM. p < 0.01 vs. NHP.
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How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.001 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.001 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.001 |
| Insufficient payload (model declined to judge) | 0.001 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".