From the Notch Signaling Pathway to Ribosome Biogenesis
Bibliographic record
Abstract
Nearly 240 WD repeat proteins have been identified from the Arabidopsis genome. Among these, some well characterized WDR proteins were shown to regulate various developmental processes in plants.1 We have recently isolated in Solanum chacoense a homolog of the Drosophila NOTCHLESS gene. In Drosophila, NOTCHLESS regulates the activity of the Notch signaling pathway through a direct interaction with the intracellular domain of the Notch receptor. Although the Notch signaling pathway does not exist in yease and plants, the NLE gene is conserved in animals, plants and yeast. Furthermore, functional conservation was suggested by expression of the plant NLE gene in Drosophila. In plants, underexpression of the plant NLE gene altered numerous developmental processes including seed development, and resulted in reduced aerial organ size and organ numbers, in delayed flowering, and in an increased stomatal index. Surprisingly, the link between these pleiotropic phenotypes is the recently discovered of the involvement of NLE in ribosome biogenesis, emphasizing its role in proper cellular growth and proliferation during plant development.
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How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.000 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.001 | 0.001 |
| Open science | 0.000 | 0.001 |
| Research integrity | 0.000 | 0.001 |
| Insufficient payload (model declined to judge) | 0.004 | 0.002 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".