Modular Access to Structurally Switchable 3D Discrete DNA Assemblies
Why this work is in the frame
A frame that forgets how it found something cannot be audited. These are the routes that admitted this work.
Bibliographic record
Abstract
In this contribution we describe a facile method to access a large number of three-dimensional discrete DNA assemblies. The approach involves the use of single-stranded and cyclic 2D DNA building blocks, of predefined geometry, as the faces or sides of the objects to be constructed. Any target three-dimensional discrete object that could be retrosynthetically broken down into a combination of the discrete 2D shapes, could in principle be easily accessed using this method. Using triangle 3, square 4, pentagon 5, and hexamer 6, we constructed triangular, cubic, pentameric, and hexameric prisms, as well as the more complex heteroprism HP and biprism BP assemblies in quantitative yields. The use of single-stranded DNA building blocks inherently allows for dynamic character and addressability. Using a series of rigidifying and eraser strands, we generated a triangular prism capable of structural oscillation between three predefined lengths. The easy access to a large number of complex three-dimensional discrete DNA objects that are also dynamic, in response to external stimuli, promises to expand the applications of 3D DNA construction in many areas of nanoscience, drug delivery, and biological chemistry.
Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.
Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.000 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.001 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.000 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it