Effect of γ-ray irradiated poly(L-lactide) on the differentiation of mouse osteoblast-like MC3T3-E1 cells
Why this work is in the frame
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Bibliographic record
Abstract
The purpose of this study was to clarify the effects of gamma-ray irradiated poly(L-lactide) (PLLA) on the proliferation and differentiation of mouse osteoblast-like MC3T3-E1 cells. The PLLA was y-irradiated at the dose of 10, 25 or 50 kGy, and the molecular weight of irradiated PLLA decreased with increasing irradiation dose. The proliferation and differentiation of MC3T3-E1 cells cultured on irradiated PLLA for 2 weeks were evaluated using micromass culture. The y-irradiation of PLLA did not affect the proliferation, but stimulated the differentiation of MC3T3-E1 cells cultured on irradiated PLLA. These results suggested that lower change in the molecular weight of PLLA was responsible for stimulation of the differentiation of MC3T3-E1 cells cultured on irradiated PLLA. Furthermore, the proliferation and calcification of MC3T3-E1 cells cultured in the medium containing low molecular weight PLLA for 2 weeks were evaluated. The low molecular weight PLLA also stimulated the calcification of MC3T3-E1 cells with no effect on the proliferation. The y-irradiation was suitable for PLLA on the differentiation of mouse osteoblasts.
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Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.001 | 0.000 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.000 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it