Regulation of the Murine IgE Antibody Response
Bibliographic record
Abstract
IgE responses to insulin species variants i.e. to bovine, ovine and porcine insulins (respectively BI, OI and PI), were investigated. H-2d mice developed an anti-BI IgE response when this antigen was administered i.p. with A1(OH)3 gel, and H-2b and H-2a,d,k mice generated anti-BI and anti-OI IgE responses, respectively, when these antigens were injected i.p. with Freund's complete adjuvant (FCA). H-2d mice, on the other hand, developed only weak to negligible anti-PI IgE responses, when this antigen was administered in A1(OH)3 or in FCA. Antibody cross-reactivity indicated that at least two populations of IgE antibodies were produced in response to BI and/or OI; one population specific for the A chain loop and a second population specific for a determinant common to several insulins. Finally, i.v. injections of conjugates of insulin with spleen lymphocytes markedly suppressed the capacity of mice to develop an anti-insulin IgE response.
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How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.000 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.001 |
| Insufficient payload (model declined to judge) | 0.002 | 0.001 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".