Electric-field-based methods for the manipulation and modification of biological cells in suspension
Bibliographic record
Abstract
We have previously described microfabricated planar electrodes and their use for electro-manipulation of various mammalian cell-lines: We used dielectrophoresis (DEP) to position U937 monocytes within a non-uniform electric field and thereby controlled the extent of membrane electro poration (EP), which resulted from pulsed electric fields. We used electro-deformation (ED) to estimate the mechanical properties of several differing mammalian cell-lines (in suspension), and compared these with confocal imaging-based analysis of the cell-cytoskeleton (CSK). Here, we summarize these and other electro-manipulations observed using the same electrode geometry; these include electrorotation, disruption, and fusion. Based on these observations, we discuss potential applications for electro manipulation within microdevice platforms that handle cells on an individual basis.
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How this classification was reachedexpand
Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.000 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.000 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one teacher head, not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".