OBSERVATIONS AND ADVERTISING: CONTROVERSIES IN THE PRESCRIBING OF HORMONE REPLACEMENT THERAPY
Bibliographic record
Abstract
Since scientists in the 1930s discovered sex hormones, hormone replacement therapy (HRT) has been a source of considerable controversy and debate. This debate continues with the publication of the results of the Women's Health Initiative, a large randomized controlled trial that has once again altered the way women and their care providers view this therapy. Over the years the evidence increasingly has suggested that HRT is not effective for the prevention of cardiovascular disease in women. However, the prevailing opinion denied this, and millions of women were prescribed estrogen with or without progestin under the assumption that cardioprotection was possible. Why did this practice continue in the face of mounting evidence of harm? In this article we will explore the role that the media and pharmaceutical companies have played in the widespread use of these hormones despite evidence of significant side effects and lack of prevention efficacy.
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How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.017 | 0.043 |
| Meta-epidemiology (narrow) | 0.000 | 0.001 |
| Meta-epidemiology (broad) | 0.001 | 0.001 |
| Bibliometrics | 0.003 | 0.008 |
| Science and technology studies | 0.001 | 0.005 |
| Scholarly communication | 0.004 | 0.005 |
| Open science | 0.002 | 0.001 |
| Research integrity | 0.006 | 0.005 |
| Insufficient payload (model declined to judge) | 0.004 | 0.001 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".