Multicentre trial in people with arthritis finds increased risk of clinically significant gastrointestinal events with diclofenac plus omeprazole compared with celecoxib
Bibliographic record
Abstract
Commentary on: Chan FK, Lanas A, Scheiman J, et al. Celecoxib versus omeprazole and diclofenac in patients with osteoarthritis and rheumatoid arthritis (CONDOR): a randomised trial. Lancet 2010;376:173–9.[OpenUrl][1][CrossRef][2][PubMed][3][Web of Science][4] Although traditional non-steroidal anti-inflammatory drugs (tNSAIDs) have been recognised to have adverse effects throughout the gastrointestinal (GI) tract, emphasis has historically centred on reducing their upper GI ulcerogenic effects.1 Randomised trials and systematic reviews have shown that misoprostol and proton pump inhibitors (PPIs) are effective at reducing the risk of tNSAID-related upper GI toxicity. The tNSAID+PPI strategy emerged as the preferred strategy for several reasons including a favourable side effect profile. Over the last 10 years, the focus has shifted towards using cyclooxygenase-2 (COX-2) inhibitors alone as another effective strategy to reduce upper GI toxicity. COX-2 inhibitors, however, have been associated with other adverse effects, and many have been withdrawn from various markets.1 Chan … [1]: {openurl}?query=rft.jtitle%253DLancet%26rft.stitle%253DLancet%26rft.aulast%253DChan%26rft.auinit1%253DF.%2BK.%26rft.volume%253D376%26rft.issue%253D9736%26rft.spage%253D173%26rft.epage%253D179%26rft.atitle%253DCelecoxib%2Bversus%2Bomeprazole%2Band%2Bdiclofenac%2Bin%2Bpatients%2Bwith%2Bosteoarthritis%2Band%2Brheumatoid%2Barthritis%2B%2528CONDOR%2529%253A%2Ba%2Brandomised%2Btrial.%26rft_id%253Dinfo%253Adoi%252F10.1016%252FS0140-6736%252810%252960673-3%26rft_id%253Dinfo%253Apmid%252F20638563%26rft.genre%253Darticle%26rft_val_fmt%253Dinfo%253Aofi%252Ffmt%253Akev%253Amtx%253Ajournal%26ctx_ver%253DZ39.88-2004%26url_ver%253DZ39.88-2004%26url_ctx_fmt%253Dinfo%253Aofi%252Ffmt%253Akev%253Amtx%253Actx [2]: /lookup/external-ref?access_num=10.1016/S0140-6736(10)60673-3&link_type=DOI [3]: /lookup/external-ref?access_num=20638563&link_type=MED&atom=%2Febmed%2F16%2F4%2F110.atom [4]: /lookup/external-ref?access_num=000280313100024&link_type=ISI
Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.
How this classification was reachedexpand
Direct model labels (unvalidated)
Per-model category and study-design labels from the labeling rounds. They are machine output, unvalidated, and the disagreement between models ships as data. No study design here is MEDLINE-validated yet.
| Model arm | Categories | Study design | Confidence |
|---|---|---|---|
| gemma | no category Domain: not available · Genre: Empirical About the Canadian research system: no · About a Canadian topic: no | Randomized trial | low |
| gpt | no category Domain: not available · Genre: Commentary About the Canadian research system: no · About a Canadian topic: no | Other design | low |
Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.003 | 0.003 |
| Meta-epidemiology (narrow) | 0.001 | 0.001 |
| Meta-epidemiology (broad) | 0.004 | 0.000 |
| Bibliometrics | 0.001 | 0.001 |
| Science and technology studies | 0.000 | 0.001 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.001 | 0.000 |
| Research integrity | 0.001 | 0.004 |
| Insufficient payload (model declined to judge) | 0.001 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedLabeled directly by 2 models reading the full record.
The models disagree on parts of this classification; every voice is preserved in the section at the end of the page.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".