Novel therapeutic strategies for impaired endothelium-dependent vascular relaxation
Bibliographic record
Abstract
Impaired vascular relaxation is a common aetiology in many cardiovascular diseases and, in most cases, disequilibria in the amounts of endothelium-derived relaxing and constricting factors is the root of problem. Endothelium-derived vasoactive factors modulate vascular tone, smooth muscle cell proliferation, blood coagulation and fibrinolysis, lipoprotein metabolism and the interaction of platelet and leukocyte with the vascular wall. Although the synthesis and release of endothelium-derived vasoactive substances are vulnerable to pathogenic insults, endothelial dysfunction can be corrected pharmacologically using inhibitors of the renin–angiotensin system, endothelin antagonists, inductors of angiogenesis and other compounds. Many recent patents have provided novel formulations of drugs targeting dysfunctional endothelium. Optimised pharmacodynamic and pharmacokinetic properties of these drugs would greatly improve their clinical applications.
Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.
How this classification was reachedexpand
Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.000 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.000 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one teacher head, not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".