Dantrolene, like fatigue, has a length‐dependent effect on submaximal force–length relationships of rat gastrocnemius muscle
Bibliographic record
Abstract
AIM: Fatigue is length-dependent; relative active force depression is greater when measured at short lengths than at long lengths. Several unsatisfactory mechanisms have been proposed to explain this length dependence of fatigue, including: damaged myofilaments, stretch of 'in-series' structures, impaired t-tubule conduction and reduced intensity of activation. Dantrolene targets the ryanodine receptors, inhibiting stimulation-induced release of Ca2+. The purpose of this study was to determine if the force depression caused by dantrolene treatment also has a length dependence. METHODS: Submaximal (single-pulse, double-pulse and 50 Hz stimulation) active force-length relationships were obtained from the medial gastrocnemius muscle of anaesthetized rats, before and after intravenous injection with dantrolene dissolved in propylene glycol. RESULTS: Dantrolene treatment was sufficient to reduce twitch amplitude by 25%. Similar to the consequences of repetitive stimulation, dantrolene treatment caused the same decrease in absolute active force across a broad range of test lengths, for twitch, double-pulse and 50 Hz contractions. Considering that active force is smaller at short lengths than at long lengths, this similar absolute force decrease represents a greater relative decrease at short lengths. Clearly, there is a length-dependent impact of attenuated Ca2+ release by dantrolene on relative active force. CONCLUSION: This study demonstrates that there is a length dependence of force depression associated with decreased Ca2+ release due to dantrolene treatment; therefore, if fatigue is due to decreased Ca2+ release, then additional length-dependent mechanisms are not required to explain the reported length dependence of force depression.
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How this classification was reachedexpand
Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.000 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.000 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one teacher head, not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".