Role of Brain Serotonin in the Circadian Rhythm of Corticosterone Secretion and the Corticotropic Response to Adrenalectomy in the Rat
Bibliographic record
Abstract
Pharmacological and neurosurgical approaches were used to determine whether central serotoninergic systems are essential to the diurnal fluctuation of plasma corticosterone (B) and the enhanced secretion of ACTH induced by adrenalectomy. Normal and 3-week adrenalectomized (ADX) male rats were either acutely treated 24 h before sacrifice with parachlorophenylalanine methyl ester (PCPA, 250 mg/kg, i.p. injection), or were subjected to lesions of the nuclei centralis superior and raphe dorsalis, chief sites of serotonin(5-HT)-containing neurons. PCPA treatment produced a significant decrease in the 5-HT and 5-hydroxyindoleacetic acid (5-HIAA) levels in the hypothalamus and dorsal hippocampus but did not abolish the plasma B rhythm. Lesions of the raphe nuclei did not abolish the diurnal rhythm of the steroid, either; they were followed, however, by a significant decrease in the 5-HT concentration of both brain structures, whereas no change was recorded in the noradrenergic (NE) level of either structure. Bilateral adrenalectomy induced a marked increase in the 5-HT concentration of the dorsal hippocampus. In the hypothalamus, the 5-HT level remained unaffected, whereas a slight increase in NE content was recorded. In ADX animals, raphe lesions significantly decreased the 5-HT concentration of the hypothalamus and dorsal hippocampus. No modification
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How this classification was reachedexpand
Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.002 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.000 | 0.001 |
| Science and technology studies | 0.000 | 0.001 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.000 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one teacher head, not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".