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Record W1969926202 · doi:10.1016/j.bbapap.2012.03.011

Phthalocyanine tetrasulfonates bind to multiple sites on natively-folded prion protein

2012· article· en· W1969926202 on OpenAlexafffund
Derek R. Dee, Amar Nath Gupta, Max Anikovskiy, Iveta Sosova, Elena Grandi, Laura Rivera, Abhilash Vincent, Angela M. Brigley, Nils O. Petersen, Michael T. Woodside

Bibliographic record

VenueBiochimica et Biophysica Acta (BBA) - Proteins and Proteomics · 2012
Typearticle
Languageen
FieldBiochemistry, Genetics and Molecular Biology
TopicPrion Diseases and Protein Misfolding
Canadian institutionsNational Institute for NanotechnologyUniversity of Alberta
FundersAlberta Innovates
KeywordsIsothermal titration calorimetryChemistryTitrationIonic strengthBinding constantMetal ions in aqueous solutionFluorescenceQuenching (fluorescence)MoleculeLigand (biochemistry)StoichiometrySurface plasmon resonanceMetalBinding siteBiophysicsInorganic chemistryAqueous solutionBiochemistryReceptorOrganic chemistryMaterials scienceBiologyNanotechnology

Abstract

fetched live from OpenAlex
No abstract in any covered source. Its absence is recorded, not treated as a negative.

No abstract. This is not a gap in this database; OpenAlex has none either. 23.3% of the frame is in this state, and the screen finds HALF as much metaresearch here, so the absence is a measured bias rather than a missing field.

How this classification was reachedexpand

Full frame distilled prediction

Teacher imitation

Not calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.

metaresearch head score (Codex)0.000
metaresearch head score (Gemma)0.000
Version: codex-gemma-dda1882f352aValidation status: machine_predicted_unvalidated
Candidate categoriesMeta-epidemiology (narrow)
Consensus categoriesnone
DomainCandidate signal: none · Consensus signal: none
Study designCandidate signal: Bench or experimental · Consensus signal: Bench or experimental
GenreCandidate signal: Empirical · Consensus signal: Empirical
Teacher disagreement score0.010
Threshold uncertainty score1.000

Codex and Gemma teacher scores by category

CategoryCodexGemma
Metaresearch0.0000.000
Meta-epidemiology (narrow)0.0010.001
Meta-epidemiology (broad)0.0000.000
Bibliometrics0.0000.000
Science and technology studies0.0000.000
Scholarly communication0.0000.000
Open science0.0000.000
Research integrity0.0000.000
Insufficient payload (model declined to judge)0.0000.000

Machine scores (provisional)

The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.

Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.

Opus teacher head0.018
GPT teacher head0.265
Teacher spread0.246 · how far apart the two teachers sit on this one work
Validation statusscore_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it

Classification

machine, unvalidated

Machine predicted; a candidate call from one teacher head, not a consensus.

Study designBench or experimental
Domainnot available
GenreEmpirical

How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".

Quick stats

Citations21
Published2012
Admission routes2
Has abstractno

Explore more

Same venueBiochimica et Biophysica Acta (BBA) - Proteins and ProteomicsSame topicPrion Diseases and Protein MisfoldingFrench-language works237,207