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Environment and development of atopy

2005· review· en· W1970713715 on OpenAlexfundno aff
John W. Upham, Patrick G. Holt

Bibliographic record

VenueCurrent Opinion in Allergy and Clinical Immunology · 2005
Typereview
Languageen
FieldMedicine
TopicAsthma and respiratory diseases
Canadian institutionsnot available
FundersNational Medical Research CouncilFaculty of Medicine and Dentistry, University of AlbertaNational Health and Medical Research Council
KeywordsMedicineAtopyImmunologyAsthma

Abstract

fetched live from OpenAlex

PURPOSE OF REVIEW: Asthma and other atopic disorders are the result of complex interactions between genetic predisposition and multiple environmental influences. However, the marked increase in asthma prevalence over recent decades is unlikely to be due to genetic changes, highlighting the contribution of environmental factors to the process of allergic sensitization. RECENT FINDINGS: This article reviews recent information on environmental influences on the development of atopy in children. Both observational and interventional studies continue to shed new light on the critical influence of early life events--such as events in pregnancy, exposure to allergens and endotoxin, pet ownership, infections, family size--and have highlighted important gene-environment interactions that modify the relationships between environmental exposures and atopic outcomes. SUMMARY: The future is likely to see a concerted effort to further define the role that these environmental exposures play in allergic sensitization and the expression of atopic diseases, in order to provide a rational platform on which to develop new methods of allergy prevention that can be targeted at high-risk children.

Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.

How this classification was reachedexpand

Full frame distilled prediction

Teacher imitation

Not calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.

metaresearch head score (Codex)0.000
metaresearch head score (Gemma)0.000
Version: codex-gemma-dda1882f352aValidation status: machine_predicted_unvalidated
Candidate categoriesnone
Consensus categoriesnone
DomainCandidate signal: none · Consensus signal: none
Study designCandidate signal: Other design · Consensus signal: none
GenreCandidate signal: Review · Consensus signal: Review
Teacher disagreement score0.996
Threshold uncertainty score0.783

Codex and Gemma teacher scores by category

CategoryCodexGemma
Metaresearch0.0000.000
Meta-epidemiology (narrow)0.0000.000
Meta-epidemiology (broad)0.0010.000
Bibliometrics0.0000.000
Science and technology studies0.0000.000
Scholarly communication0.0000.000
Open science0.0000.000
Research integrity0.0000.001
Insufficient payload (model declined to judge)0.0000.000

Machine scores (provisional)

The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.

Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.

Opus teacher head0.147
GPT teacher head0.443
Teacher spread0.296 · how far apart the two teachers sit on this one work
Validation statusscore_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it

Classification

machine, unvalidated

Machine predicted; a candidate call from one teacher head, not a consensus.

The models applied no category: nothing in the taxonomy fit this work.
Study designOther design
Domainnot available
GenreReview

How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".

Quick stats

Citations77
Published2005
Admission routes1
Has abstractyes

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