The patient's journey: rheumatoid arthritis
Bibliographic record
Abstract
The mapRheumatoid arthritis (RA) is a common chronic disorder of disturbed immunity that affects about 1% of adults in the United Kingdom.It typically develops in middle or late life and is three times more common in women than it is in men.It is characterised by joint pain, swelling, and stiffness, particularly of the small joints of the hands and feet.Its onset varies between gradual and acute.The classic pathological features include inflammation in the synovial lining joints and tendon sheaths.Patients feel sore, especially in the morning.Its natural course is variable, with disease severity changing over time, although in many patients there is increasing joint damage and functional disability.From the perspective of patients, pain, reduced mobility, fatigue, and psychological effects, such as depression, are the dominant concerns.In contrast, clinicians generally focus on measurable disease activity, along with radiographically identifiable progressive joint damage.They aim to achieve remission of the synovitis and to delay or limit functional disability, to minimise the effect on work participation and dependency on family, carers, and the health service.Optimal treatment is now seen to be care provided by a multidisciplinary team and includes education, advice, exercise, drug treatment, and joint surgery in late disease.Treatment options comprise analgesics, non-steroidal inflammatory drugs, disease modifying drugs such as methotrexate, steroids, and the new biologicals (for example, anti-tumour necrosis factor agents).Despite these various treatments, the key features of rheumatoid arthritis are the unpredictability of both the acute flare-ups and of how patients respond to the drugs.This means that control over the illness is often difficult and requires patients and professionals to continuously adapt to the disease state.
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How this classification was reachedexpand
Direct model labels (unvalidated)
Per-model category and study-design labels from the labeling rounds. They are machine output, unvalidated, and the disagreement between models ships as data. No study design here is MEDLINE-validated yet.
| Model arm | Categories | Study design | Confidence |
|---|---|---|---|
| gemma | no category Domain: not available · Genre: Review About the Canadian research system: no · About a Canadian topic: no | Not applicable | low |
| gpt | no category Domain: not available · Genre: Review About the Canadian research system: no · About a Canadian topic: no | Not applicable | low |
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.001 | 0.005 |
| Meta-epidemiology (narrow) | 0.001 | 0.000 |
| Meta-epidemiology (broad) | 0.002 | 0.001 |
| Bibliometrics | 0.001 | 0.001 |
| Science and technology studies | 0.001 | 0.001 |
| Scholarly communication | 0.002 | 0.003 |
| Open science | 0.001 | 0.001 |
| Research integrity | 0.004 | 0.004 |
| Insufficient payload (model declined to judge) | 0.013 | 0.009 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedLabeled directly by 2 models reading the full record.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".