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Record W1970907754 · doi:10.1136/bmj.330.7496.857

Drugs for Alzheimer's disease and related dementias

2005· letter· en· W1970907754 on OpenAlexaff
Serge Gauthier

Bibliographic record

VenueBMJ · 2005
Typeletter
Languageen
FieldMedicine
TopicDementia and Cognitive Impairment Research
Canadian institutionsMcGill University
Fundersnot available
KeywordsAlzheimer's diseaseDiseaseDementiaMedicineData scienceComputer sciencePathology

Abstract

fetched live from OpenAlex

Clear rules about stopping treatment in individual patients are needed The article by Ballard et al in this issue (p 874) offers an opportunity to discuss the role of drugs in the treatment of Alzheimer's disease and related dementias.1 This investigator driven randomised clinical trial has tested the hypothesis that the atypical neuroleptic quetiapine and the cholinesterase inhibitor rivastigmine would be better than placebo for treating agitation in institutionalised patients in severe stages of Alzheimer's disease. Using measures of agitation (the Cohen-Mansfield agitation inventory) and cognition (the severe impairment battery) appropriate for this stage of dementia, the authors showed that agitation improved equally in the three arms of the trial but a measurable decline in cognition occurred in patients taking quetiapine. …

Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.

How this classification was reachedexpand

Full frame machine prediction

Teacher imitation

Not calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.

metaresearch head score (Codex)0.002
metaresearch head score (Gemma)0.013
Version: metacan-v3-hybrid-931329e0061cValidation status: machine_predicted_unvalidated
Candidate categoriesnone
Consensus categoriesnone
DomainCandidate signal: none · Consensus signal: none
Study designCandidate signal: Not applicable · Consensus signal: Not applicable
GenreCandidate signal: Commentary · Consensus signal: Commentary
Teacher disagreement score0.021
Threshold uncertainty score0.023

Distilled classifier scores by category (both heads)

CategoryCodexGemma
Metaresearch0.0020.013
Meta-epidemiology (narrow)0.0010.000
Meta-epidemiology (broad)0.0010.001
Bibliometrics0.0010.001
Science and technology studies0.0020.002
Scholarly communication0.0020.002
Open science0.0010.001
Research integrity0.0210.015
Insufficient payload (model declined to judge)0.0070.008

Machine scores (provisional)

The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.

Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.

Opus teacher head0.028
GPT teacher head0.347
Teacher spread0.319 · how far apart the two teachers sit on this one work
Validation statusscore_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it

Classification

machine, unvalidated

Machine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.

The models applied no category: nothing in the taxonomy fit this work.
Study designNot applicable
Domainnot available
GenreCommentary

How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".

Quick stats

Citations12
Published2005
Admission routes1
Has abstractyes

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Same venueBMJSame topicDementia and Cognitive Impairment ResearchFrench-language works237,207