Sex steroids regulate TSH-induced thyroid growth during sexual maturation in Wistar rats
Bibliographic record
Abstract
Sex steroids have been reported to influence thyroid pathogenesis in human and experimental animals. However, there is no much report on the effect of sex steroids in the growth of normal thyroid. The present study is an attempt to know TSH-induced thyroid growth during sexual maturation in Wistar rats. Wistar rats of day 1 to day 150 postpartum (pp) were used in the present study. Thyroid growth indices such as absolute and relative thyroid weights, concentration of DNA in the thyroid, mitotic index and numerical density of thyrocytes, hormonal profiles in the serum and thyroid tissue such as thyrotropin (TSH), thyroid hormones, testosterone and estradiol, and receptors for TSH, androgen and estrogen in the thyroid were estimated. A gender-specific shift in the pattern of serum TSH and TSH-R was observed during 30-45 days of postnatal life, the period at which steroidogenesis by testes or ovaries of rats are reactivated. Testosterone in males and estradiol in females modulate thyroid growth through TSH. It is concluded from the present study that changes in the sex steroid status between male and female rats have a definite influence on the pattern of thyroid growth and TSH.
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How this classification was reachedexpand
Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.000 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.001 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.000 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one teacher head, not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".