Acute nonlymphocytic leukemia presenting with pancytopenia
Bibliographic record
Abstract
A 55-year-old woman being worked up for possible bladder prolapse was found to have pancytopenia. She had no prior history of malignancies or exposure to chemotherapy or radiation. Her CBC showed WBC 1.0 10 9 /L, neutrophils 0.14 10 9 /L, hemoglobin 99 g/L, MCV 100 fL, and platelet count 61 10 9 /L. A peripheral blood smear confirmed the pancytopenia and bone marrow aspirate revealed numerous medium to large monomorphic blast cells (40%) with basophilic cytoplasm containing vacuoles (panel A). Several of these blast cells had an immature folded-in nucleus with nucleoli and vacuolation (panel B). Flow cytometric analysis demonstrated a population of cells positive for CD34, CD117, CD13, CD33, human leukocyte Ag-DR, CD15, and MPO positive consistent with a myeloblast population. Cytogenetic studies revealed a complex karyotype with the presence of trisomies 8 and 21 and deletion 17p. The patient was admitted to the hospital and started on standard induction chemotherapy with cytarabine and daunorubicin for acute nonlymphocytic leukemia.
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How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.002 |
| Meta-epidemiology (narrow) | 0.001 | 0.000 |
| Meta-epidemiology (broad) | 0.001 | 0.000 |
| Bibliometrics | 0.001 | 0.001 |
| Science and technology studies | 0.001 | 0.000 |
| Scholarly communication | 0.001 | 0.001 |
| Open science | 0.000 | 0.001 |
| Research integrity | 0.002 | 0.001 |
| Insufficient payload (model declined to judge) | 0.003 | 0.001 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".