Active renin concentration and the aldosterone/renin ratio in screening primary aldosteronism
Bibliographic record
Abstract
The ratio of plasma aldosterone to renin level (aldo/renin ratio) is the preferred screening approach for distinguishing patients with essential hypertension (EHT) from those with primary aldosteronism (PAL). Until now, no reference values have been available for reporting the aldo/renin ratio using plasma active renin concentration (ng/L) instead of plasma renin activity (ng/ml/h). We studied 206 subjects who had either normal blood pressure (controls), EHT or PAL. Plasma active renin concentration was measured by immunoradiometric assay (Biorad, Renin III Generation). Plasma aldo was measured by RIA and expressed in SI units (pmol/L) and in traditional units (ng/dl). The table provides the mean ± SEM of plasma aldo values (pmol/L and ng/dl), plasma active renin concentrations (ng/L) and aldo/renin ratios (pmol/ng and ng/dl/ng/L). EHT patients usually have aldo/renin ratios below 100 (pmol/ng) or 3.6 (ng/dl/ng/L), whereas ratios for patients with PAL are above 140 (pmol/ng) or 5 (ng/dl/ng/L). Results that fall between 100 and 140 (3.6 and 5) suggest a need for repeat testing.
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How this classification was reachedexpand
Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.001 | 0.000 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.001 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.000 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one teacher head, not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".