Reversible Posterior Leucoencephalopathy Syndrome Following Duloxetine: A Case Report and Review of Literature
Bibliographic record
Abstract
Reversible Posterior Leucoencephalopathy Syndrome (RPLS) is a disorder characterized by headaches, confusion, and/or decreased level of consciousness, seizures, and visual changes. A 58-year-old female was found unresponsive, with generalized rigidity and urinary incontinence for unknown duration. On presentation, she was febrile, tachycardic, tachypneic, and hypertensive. Neurological exam showed increased muscle tone and brisk deep tendon reflexes. Brain MRI revealed gyriform edema and white matter hypodensities in parieto-occipital regions consistent with RPLS. Discontinuation of duloxetine, one of her home medications, led to resolution of symptoms. We report this case to discuss the syndrome of RPLS and propose the role of duloxetine in causing hypertension and cerebral vasoconstriction leading to RPLS. To our knowledge, this is the first reported case of RPLS resulting from the use of duloxetine. doi:10.4021/jmc98w
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How this classification was reachedexpand
Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.001 | 0.004 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.001 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.001 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one teacher head, not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".